Maria Cláudia Gonçalves de Oliveira

• Abstract

  Despite the clinical relevance of chronic muscle pain, the mechanisms underlying its chronification are not fully elucidated. Recent experiments of our laboratory demonstrate that acute and chronic inflammatory muscle pain are characterized by an increase in macrophages with a pro-inflammatory phenotype and that in the acute phase, but not in the chronic, there is an increase in IL-1² cyt…

  Chronic pain and its prevention by physical exercise: cellular signaling mechanisms involving muscular, immunological and nervous system, AP.R

• Abstract

  Chronic musculoskeletal pain are a world health problem with high socio-economic impact. Currently, several mechanisms are known that modulate acute muscle pain. However, the mechanisms underlying transition of acute to chronic pain, as well as, the chronicity of pain, are poorly understood. The pharmacological approach is not necessarily efficient to control chronic muscle pain. This is …

  Exercise-induced prevention of chronicity of muscle pain: involvement of neuroimmune mechanisms, AP.R

• Abstract

  Among the kinds of pain that affect people throughout their lives, muscle pain, induced by sustained isometric contraction is one of the most prevalent kinds of pain and has an important socio-economic impact. However, despite their clinical relevance, the molecular mechanisms involved in the development of muscle pain induced by sustained isometric contraction are unknown. This is mainly…

  Development of a new model for the study of muscle hyperalgesia and the involvement of P2X3 and P2X2/3 receptors in muscle hyperalgesia, AP.JP

• Abstract

  Chronic musculoskeletal pain is a worldwide public health problem with important socioeconomic impact. Nowadays, different modulatory mechanisms of acute muscular pain are already known. However, little is known about the mechanisms underlying the transition from acute pain to chronic as well as its maintenance. In chronic pain conditions, pharmacological therapy is not always efficient, …

  Inflammatory mechanisms underlying muscle pain chronification and its prevention by physical exercise: study of macrophages, PPAR gamma and P2X4 receptors involvment, BP.DR

• Abstract

  Muscle pain has an important clinical relevance and regular exercise has been described as a good alternative therapy, not only by reducing pain, but also by the absence of the common side effects of commercially available analgesics. However, it is known that the body adapts to exercise intensity over time and that individuals with chronic pain conditions respond to exercise differently …

  Exercise Induces Hypoalgesia: Effect of chronic and individualized exercise and evaluation of the involvement of PPAR-³ receptors in this process, BP.MS

• Abstract

  Among the kinds of pain that affect people throughout their lives, muscle pain, specially the one induced by sustained isometric contraction, is one of the most prevalent kinds of pain and has an important socio-economic impact. However, despite their clinical relevance, the inflammatory molecular mechanisms involved in the development of muscle pain induced by sustained isometric contrac…

  Involvement of inflammatory mediators and of P2X3 receptors on muscle hyperalgesia induced by sustained isometric contraction in rats, BP.MS

(Only some records are available in English at this moment)

• Abstract

  Skeletal muscle has been presented as a highly plastic tissue in response to physical exercise metabolic demands and these effects are relevant for the prevention of several diseases. Little is known about how much physical exercise metabolic adaptations in the skeletal muscle tissue may be related to the resolution of inflammatory pain in the nociceptive primary neurons and prevention of…

  Investigation of a crosstalk pathway between skeletal muscle and sensory neurons: effects of physical exercise-induced PGC-1a1 in skeletal muscle on dorsal roots ganglion activation and metabolism, BE.EP.DR

• Abstract

  Low back pain (LBP) is one of the most common chronic pain conditions in humans. In most cases the origin of the pain cannot be determined by conventional clinical diagnostic methods (so called non-specific LBP). Data about interventions that could prevent the transition or abolish existing chronic non-specific LBP are rare. The classical treatment for non-specific low back pain is the u…

  Effects of exercise treatment on the responsiveness of dorsal horn neurons in an animal model of low back pain, BE.EP.MS

• Abstract

  The chronic musculoskeletal pain is a great public health problem. They affect 47% of population and, because they are associated with muscle fatigue, they induce a decrease in physical activity and the ability to perform the activities of daily living. Although the clinical relevance of chronic muscle pain associated with muscle fatigue, the molecular mechanisms involved with this proces…

  Role of P2X4 receptors on fatigue-enhanced muscle pain, BE.PQ